| Registro completo |
| Provedor de dados: |
OAK
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| País: |
Japan
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| Título: |
Active Immunization Against 5α-androstane-3α, 17β-diol Increases Ovulation Rate in Merino Ewes
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| Autores: |
TETSUKA, Masafumi
NANCARROW, Colin. D.
手塚, 雅文
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| Data: |
2001
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| Ano: |
2001
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| Palavras-chave: |
Ovulation rate
Sheep
Immunization
5a-reduced androgen
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| Resumo: |
Cyclic Merino ewes were immunized three times against 5α−androstane-3α,17β-diol (3α-diol) at three week intervals (weeks 0,3 and 6). After the third immunization, estrous cycles were synchronized by a series of PG injections and intensive blood samples were obtained for gonadotropin analyses during the mid-luteal phase and during the early follicular phase. Ovulation rates were determined after each immunization and subsequent cloprostenol (PG)-induced luteolysis (weeks 3, 6, 8 and 11). After the second immunization, daily blood samples were obtained and concentrations of plasma progesterone (P) were measured. Immunization against 3α-diol significantly increased the ovulation rate after the second and third immunizations and at week 10 (P<0.01, P<0.01 and P<0.05 respectively). It also induced anovulation in several ewes. Plasma concentrations of P were significantly increased by 3α-diol immunization (P<0.01). Pulse frequency of LH and concentrations of FSH were also increased during the luteal phase (P<0.01 and P<0.05 respectively). There was a significant correlation between the mean concentrations of FSH during the luteal phase and the subsequent ovulation rates (P<0.01). These results indicate that immunization against 3α-diol increases ovulation rate in ewes and its effect was, at least partially, exerted by increased plasma concentrations of FSH.
http://www.jstage.jst.go.jp/article/jrd/47/1/47_7/_article/-char/ja/
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| Idioma: |
Inglês
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| Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/3033
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| Editor: |
日本繁殖生物学会
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| Formato: |
application/pdf
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| Direitos: |
日本繁殖生物学会
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